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L-histidine biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
N-1-(5'-phosphoribosyl)-ATP + H2O <=> 1-(5-phosphoribosyl)-AMP + diphosphate + H+ 3.6.1.31 phosphoribosyl-ATP diphosphatase

N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide_ribonucleotide <=> phosphoribulosylformimino-AICAR-phosphate 5.3.1.16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase

L-histidinal + NAD+ + H2O <=> H+ + L-histidine + NADH 1.1.1.23 histidinol dehydrogenase

N-1-(5'-phosphoribosyl)-ATP + diphosphate <=> ATP + 5-phospho-alpha-D-ribose_1-diphosphate 2.4.2.17 ATP phosphoribosyltransferase

L-Histidinol + NAD+ <=> H+ + L-histidinal + NADH 1.1.1.23 histidinol dehydrogenase

D-erythro-1-(imidazol-4-yl)glycerol_3-phosphate <=> 3-(Imidazol-4-yl)-2-oxopropyl_phosphate + H2O 4.2.1.19 imidazoleglycerol-phosphate dehydratase

L-Histidinol_phosphate + 2-oxoglutarate <=> 3-(Imidazol-4-yl)-2-oxopropyl_phosphate + L-glutamate 2.6.1.9 histidinol-phosphate transaminase

L-Histidinol_phosphate + H2O <=> L-Histidinol + phosphate 3.1.3.15 histidinol-phosphatase
3.1.3.2 acid phosphatase


phosphoribulosylformimino-AICAR-phosphate + L-glutamine <=> H+ + L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol_3-phosphate + 5-aminoimidazole-4-carboxamide_ribonucleotide 2.4.2
4.3.1.B2
4.3.2.10 imidazole glycerol-phosphate synthase



1-(5-phosphoribosyl)-AMP + H2O <=> N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide_ribonucleotide 3.5.4.19 phosphoribosyl-AMP cyclohydrolase

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